Whorton Lab -- Vollum Institute, OHSU



Structural basis for mammalian nucleotide sugar transport.

Ahuja S, Whorton MR.

ELife. 2019 Apr 15;8. pii: e45221. more info...


Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.

Martin GM, Yoshioka C, Rex EA, Fay JF, Xie Q, Whorton MR, Chen JZ, Shyng SL.

ELife. 2017 Jan 16;6. pii: e24149. more info...


Structural biology: Calcium-activated proteins visualized.

Whorton M.

Nature. 2014 Dec 11;516(7530):176-8. more info...


Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system.

Wang W, Whorton MR, MacKinnon R.

ELife. 2014 Jul 20;3:e03671. more info...


X-ray structure of the mammalian GIRK2-βγ G-protein complex.

Whorton MR, MacKinnon R.

Nature. 2013 Jun 13;498(7453):190-7. more info...


Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium.

Whorton MR, MacKinnon R.

Cell. 2011 Sep 30;147(1):199-208. more info...


The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.

Yao XJ, Vélez Ruiz G, Whorton MR, Rasmussen SG, DeVree BT, Deupi X, Sunahara RK, Kobilka B.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9501-6. more info...


Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer.

Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK.

J Biol Chem. 2008 Feb 15;283(7):4387-94. more info...


A CE assay for the detection of agonist-stimulated adenylyl cyclase activity.

Cunliffe JM, Whorton MR, Sunahara RK, Kennedy RT.

Electrophoresis. 2007 Jun ;28(12):1913-20. more info...


A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.

Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara RK.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7682-7. more info...


SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.

Benson MD, Li QJ, Kieckhafer K, Dudek D, Whorton MR, Sunahara RK, Iñiguez-Lluhí JA, Martens JR.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1805-10. more info...


ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6.

Giguère P, Rochdi MD, Laroche G, Dupré E, Whorton MR, Sunahara RK, Claing A, Dupuis G, Parent JL.

Cell Signal. 2006 Nov ;18(11):1988-94. more info...


Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues.

Jameson EE, Roof RA, Whorton MR, Mosberg HI, Sunahara RK, Neubig RR, Kennedy RT.

J Biol Chem. 2005 Mar 4;280(9):7712-9. more info...


Chemical and functional analysis of hydroxyurea oral solutions.

Heeney MM, Whorton MR, Howard TA, Johnson CA, Ware RE.

J Pediatr Hematol Oncol. 2004 Mar ;26(3):179-84. more info...


Identification of hemochromatosis gene polymorphisms in chronically transfused patients with sickle cell disease.

Jeng MR, Adams-Graves P, Howard TA, Whorton MR, Li CS, Ware RE.

Am J Hematol. 2003 Dec ;74(4):243-8. more info...